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Chemical Structure : PS423
Catalog No.: PC-62480Not For Human Use, Lab Use Only.
PS 423 is a substrate-selective inhibitor of PDK1, inhibits the phosphorylation and activation of S6K without affecting the PKB/Akt signaling pathway in HEK293 cells, the prodrug of PS210.
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PS 423 is a substrate-selective inhibitor of PDK1, inhibits the phosphorylation and activation of S6K without affecting the PKB/Akt signaling pathway in HEK293 cells, the prodrug of PS210.
PS423 inhibits glucose uptake in C2C12 myoblasts.
PS423 inhibits S6K but not PKB/Akt downstream signaling in muscle cells.
| M.Wt | 524.445 | |
| Formula | C25H23F3O9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Busschots K, et al. Chem Biol. 2012 Sep 21;19(9):1152-63.
2. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14.
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