Chemical Structure : PS423
CAS No.: 1221964-37-9
Catalog No.: PC-62480Not For Human Use, Lab Use Only.
PS423 (PS-423, PS 423) is a substrate-selective inhibitor of Phosphoinositide-dependent protein kinase 1 (PDK1), inhibits the phosphorylation and activation of S6K without affecting the PKB/Akt signaling pathway in HEK293 cells, the prodrug of PS210.
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PS423 (PS-423, PS 423) is a substrate-selective inhibitor of Phosphoinositide-dependent protein kinase 1 (PDK1), inhibits the phosphorylation and activation of S6K without affecting the PKB/Akt signaling pathway in HEK293 cells, the prodrug of PS210.
PS423 inhibits glucose uptake in C2C12 myoblasts.
PS423 inhibits S6K but not PKB/Akt downstream signaling in muscle cells.
| M.Wt | 524.445 | |
| Formula | C25H23F3O9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Bis(acetoxymethyl) 2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]malonate |
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1. Busschots K, et al. Chem Biol. 2012 Sep 21;19(9):1152-63.
2. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14.

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