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PS423

Chemical Structure : PS423

CAS No.: 1221964-37-9

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PS423 (PS 423)

Catalog No.: PC-62480Not For Human Use, Lab Use Only.

PS 423 is a substrate-selective inhibitor of PDK1, inhibits the phosphorylation and activation of S6K without affecting the PKB/Akt signaling pathway in HEK293 cells, the prodrug of PS210.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PS 423 is a substrate-selective inhibitor of PDK1, inhibits the phosphorylation and activation of S6K without affecting the PKB/Akt signaling pathway in HEK293 cells, the prodrug of PS210.
    PS423 inhibits glucose uptake in C2C12 myoblasts.
    PS423 inhibits S6K but not PKB/Akt downstream signaling in muscle cells.

    Physicochemical Properties

    M.Wt 524.445
    Formula C25H23F3O9
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Bis(acetoxymethyl) 2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]malonate

    References

    1. Busschots K, et al. Chem Biol. 2012 Sep 21;19(9):1152-63.

    2. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14.

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