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OSU-03013

Chemical Structure : OSU-03013

CAS No.: 742112-34-1

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OSU-03013 (OSU 03013, OSU03013)

Catalog No.: PC-60606Not For Human Use, Lab Use Only.

OSU-03013 (OSU 03013, OSU03013) is a potent, orally active 3-phosphoinositide-dependent kinase-1 (PDK-1) inhibitor with IC50 of 2 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    OSU-03013 (OSU 03013, OSU03013) is a potent, orally active 3-phosphoinositide-dependent kinase-1 (PDK-1) inhibitor with IC50 of 2 uM.
    OSU-03013 induces apoptosis in PC-3 cells at low microM range, causes Akt dephosphorylation and inhibition of p70 S6 kinase activity.
    OSU-03013 displays cytotocixity against a panel of 60 cell lines with mean GI50 of 3 uM.

    Physicochemical Properties

    M.Wt 445.449
    Formula C25H18F3N5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl-guanidine

    References

    1. Baryawno N, et al. Cancer Res. 2010 Jan 1;70(1):266-76.

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