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Chemical Structure : OSU-03013
Catalog No.: PC-60606Not For Human Use, Lab Use Only.
OSU-03013 (OSU 03013, OSU03013) is a potent, orally active 3-phosphoinositide-dependent kinase-1 (PDK-1) inhibitor with IC50 of 2 uM.
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OSU-03013 (OSU 03013, OSU03013) is a potent, orally active 3-phosphoinositide-dependent kinase-1 (PDK-1) inhibitor with IC50 of 2 uM.
OSU-03013 induces apoptosis in PC-3 cells at low microM range, causes Akt dephosphorylation and inhibition of p70 S6 kinase activity.
OSU-03013 displays cytotocixity against a panel of 60 cell lines with mean GI50 of 3 uM.
| M.Wt | 445.449 | |
| Formula | C25H18F3N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Baryawno N, et al. Cancer Res. 2010 Jan 1;70(1):266-76.
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