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CU05-1189

Chemical Structure : CU05-1189

CAS No.: 2771402-24-3

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CU05-1189 (CU 05-1189)

Catalog No.: PC-21484Not For Human Use, Lab Use Only.

CU05-1189 is a non-peptide, allosteric inhibitor of the pleckstrin homology (PH) domain of PDK1, specifically inhibits Akt signaling pathway.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CU05-1189 is a non-peptide, allosteric inhibitor of the pleckstrin homology (PH) domain of PDK1, specifically inhibits Akt signaling pathway.
CU05-1189 (2 uM) inhibits VEGF-induced proliferation of HUVECs, blocks VEGF-induced endothelial cell migration, invasion, and tube formation.
CU05-1189 inhibits the PDK1/Akt signaling pathway by suppressing membrane localization of PDK1.
CU05-1189 exerts antiangiogenic effects in matrigel plugs in the murine Matrigel plug assays.
CU05-1189 (50 mg/kg, oral) inhibits tumor angiogenesis and growth in an A549 xenograft mouse model.

Physicochemical Properties

M.Wt 405.45
Formula C24H21F2N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-(1-aminocyclobutyl)phenyl)-2-(6,7-difluoro-9H-carbazol-2-yl)acetamide

References

1. Jeongeun Park, et al. Front Pharmacol. 2023 Nov 16:14:1275749.

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