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Chemical Structure : BX-912
CAS No.: 702674-56-4
Catalog No.: PC-42781Not For Human Use, Lab Use Only.
BX-912 (BX912) is a potent, selective and ATP-competitive inhibitor of PDK1 with IC50 of 26 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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BX-912 (BX912) is a potent, selective and ATP-competitive inhibitor of PDK1 with IC50 of 26 nM.
BX-912 blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induces apoptosis.
| M.Wt | 471.3536 | |
| Formula | C20H23BrN8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-Pyrrolidinecarboxamide, N-[3-[[5-bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]- |
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1. Feldman RI, et al. J Biol Chem. 2005 May 20;280(20):19867-74.
2. Mashukova A, et al. Mol Biol Cell. 2012 May;23(9):1664-74.
3. Sturm EM, et al. Eur J Immunol. 2015 May;45(5):1548-59.
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