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BX-912

Chemical Structure : BX-912

CAS No.: 702674-56-4

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BX-912 (BX912, BX 912)

Catalog No.: PC-42781Not For Human Use, Lab Use Only.

BX-912 (BX912) is a potent, selective and ATP-competitive inhibitor of PDK1 with IC50 of 26 nM.

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5 mg $88 In stock
10 mg $128 In stock
25 mg $198 In stock
50 mg $328 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BX-912 (BX912) is a potent, selective and ATP-competitive inhibitor of PDK1 with IC50 of 26 nM.
BX-912 blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induces apoptosis.

Physicochemical Properties

M.Wt 471.3536
Formula C20H23BrN8O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-Pyrrolidinecarboxamide, N-[3-[[5-bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-

References

1. Feldman RI, et al. J Biol Chem. 2005 May 20;280(20):19867-74.

2. Mashukova A, et al. Mol Biol Cell. 2012 May;23(9):1664-74.

3. Sturm EM, et al. Eur J Immunol. 2015 May;45(5):1548-59.

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