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Chemical Structure : PDK1 agonist PS48
CAS No.: 1180676-32-7
Catalog No.: PC-73258Not For Human Use, Lab Use Only.
PDK1 agonist PS48 is a small molecule allosteric PDK1 agonist, PS48 is active at 10 nM to 1 μM in restoring normal insulin-dependent Akt activation and in mitigating Aβi peptide toxicity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $348 | In stock | |
| 250 mg | Get quote |
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PDK1 agonist PS48 is a small molecule allosteric PDK1 agonist, PS48 is active at 10 nM to 1 μM in restoring normal insulin-dependent Akt activation and in mitigating Aβi peptide toxicity.
PS48 restores Akt activation in β-amyloid expressing cells.
PS48 partly restores the suppression of LTP by Aβ42, inhibited Akt phosphorylation (Akt activation) and GSK3β phosphorylation (Akt activity).
| M.Wt | 286.755 | |
| Formula | C17H15ClO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(Z)-5-(4-Chlorophenyl)-3-phenylpent-2-enoic acid |
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1. Henry Querfurth, et al. PLoS One. 2022 Jan 21;17(1):e0261696.
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