Catalog No.: PC-73258Not For Human Use, Lab Use Only.
PDK1 agonist PS48 is a small molecule allosteric phosphoinositide-dependent protein kinase-1 (PDK-1) agonist, PS48 is active at 10 nM to 1 μM in restoring normal insulin-dependent Akt activation and in mitigating Aβi peptide toxicity.
PDK1 agonist PS48 is a small molecule allosteric phosphoinositide-dependent protein kinase-1 (PDK-1) agonist, PS48 is active at 10 nM to 1 μM in restoring normal insulin-dependent Akt activation and in mitigating Aβi peptide toxicity.
PS48 restores Akt activation in β-amyloid expressing cells.
PS48 partly restores the suppression of LTP by Aβ42, inhibited Akt phosphorylation (Akt activation) and GSK3β phosphorylation (Akt activity).
Physicochemical Properties
M.Wt
286.755
Formula
C17H15ClO2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(Z)-5-(4-Chlorophenyl)-3-phenylpent-2-enoic acid
References
1. Henry Querfurth, et al. PLoS One. 2022 Jan 21;17(1):e0261696.
