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Chemical Structure : PDK1 inhibitor 7
Catalog No.: PC-61111Not For Human Use, Lab Use Only.
A potent, selective PDK1 inhibitor with IC50 of 1 nM, displays >3,000-fold selectivity against a panel of 256 kinases.
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A potent, selective PDK1 inhibitor with IC50 of 1 nM, displays >3,000-fold selectivity against a panel of 256 kinases; specifically inhibits cellular PDK1 T-loop phosphorylation (Ser-241), inhibits p-RSK S221 in PC-3 cells with EC50 of 300 nM, inhibits colony formation in a subset of cancer cell lines (4 of 10) and primary xenograft tumor lines (9 of 57).
| M.Wt | 516.505 | |
| Formula | C28H22F2N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nagashima K, et al. J Biol Chem. 2011 Feb 25;286(8):6433-48.
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