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Chemical Structure : BX430
CAS No.: 688309-70-8
Catalog No.: PC-21244Not For Human Use, Lab Use Only.
BX430 is a potent, highly selective and allosteric antagonist of P2X4 receptor channel with IC50 of 0.54 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $488 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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BX430 is a potent, highly selective and allosteric antagonist of P2X4 receptor channel with IC50 of 0.54 uM.
BX430 shows no functional impact on all other P2X subtypes, namely, P2X1-P2X3, P2X5, and P2X7.
BX430 is a potent antagonist of zebrafish P2X4 but has no effect on rat and mouse P2X4 orthologs.
BX430 effectively suppresses ATP-evoked and ivermectin-potentiated membrane permeabilization induced by P2X4 pore dilation.
| M.Wt | 413.11 | |
| Formula | C15H15Br2N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(2,6-dibromo-4-isopropyl-phenyl)-3-(3-pyridyl)urea |
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1. Ase AR, et al. Mol Pharmacol. 2015 Apr;87(4):606-16.
2. Layhadi JA, et al. J Immunol. 2018 Feb 1;200(3):1159-1168.
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