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BX 667

Chemical Structure : BX 667

CAS No.: 937395-08-9

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BX 667 (BX667, BX-667)

Catalog No.: PC-61586Not For Human Use, Lab Use Only.

BX 667 is a potent P2Y12 receptor antagonist that blocks ADP-induced platelet aggregation in human, dog and rat blood (IC50=97, 317 and 3000 nM respectively).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BX 667 is a potent P2Y12 receptor antagonist that blocks ADP-induced platelet aggregation in human, dog and rat blood (IC50=97, 317 and 3000 nM respectively).
    BX 667 is a potential antiplatelet therapeutic agent.

    Physicochemical Properties

    M.Wt 586.64
    Formula C29H38N4O9
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-4-(4-((1-ethoxy-2-methyl-1-oxopropan-2-yl)oxy)-7-methylquinoline-2-carboxamido)-5-(4-(ethoxycarbonyl)piperazin-1-yl)-5-oxopentanoic acid

    References

    1. Wang YX, et al. Thromb Haemost. 2007 May;97(5):847-55.

    2. Bryant J, et al. Thromb Res. 2008;122(4):523-32.

    3. Post JM, et al. Thromb Res. 2008;122(4):533-40.

    4. Siller-Matula JM, et al. Br J Pharmacol. 2010 Feb 1;159(3):502-17.

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