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Chemical Structure : Barasertib
CAS No.: 722543-31-9
Catalog No.: PC-42342Not For Human Use, Lab Use Only.
Barasertib (AZD1152) is a potent, highly selective Aurora B inhibitor with IC50 of 0.37 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $160 | In stock | |
| 50 mg | $656 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote |
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Barasertib (AZD1152) is a potent, highly selective Aurora B inhibitor with IC50 of 0.37 nM.
Barasertib (AZD1152) displays >1,000-fold selectivity over Aurora B kinase.
Barasertib (AZD1152) induces growth arrest and apoptosis in human acute leukemia cells in vitro and in vivo.
| M.Wt | 587.5398 | |
| Formula | C26H31FN7O6P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)- |
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1. Mortlock AA, et al. J Med Chem. 2007 May 3;50(9):2213-24.
2. Yang J, et al. Blood. 2007 Sep 15;110(6):2034-40.
3. Wilkinson RW, et al. Clin Cancer Res. 2007 Jun 15;13(12):3682-8.et al.
4. Evans RP, et al. Br J Haematol. 2008 Feb;140(3):295-302.
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