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Chemical Structure : Barbadin
Catalog No.: PC-61188Not For Human Use, Lab Use Only.
Barbadin is a small molecule that selectively inhibits the β-arrestin/β2-adaptin interaction (IC50=19.1/15.6 uM for β-arrestin1/2) without effect on the formation of receptor/β-arrestin complexes.
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Barbadin is a small molecule that selectively inhibits the β-arrestin/β2-adaptin interaction (IC50=19.1/15.6 uM for β-arrestin1/2) without effect on the formation of receptor/β-arrestin complexes; selectively inhibits the β-arrestin/AP2 interaction, blocks agonist-promoted endocytosis of the prototypical GPCR β2AR, V2R and AT1R, but does not affect β-arrestin-independent (transferrin) or AP2-independent (endothelin-A) receptor internalization, fully blocks V2R-stimulated ERK1/2 activation and blunts cAMP accumulation promoted by both V2R and β2AR.
| M.Wt | 333.409 | |
| Formula | C19H15N3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Beautrait A, et al. Nat Commun. 2017 Apr 18;8:15054.
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