Bay 65-1942 hydrochloride | IKKβ inhibitor

Chemical Structure : Bay 65-1942 hydrochloride

CAS No.: 600734-06-3

Bay 65-1942 hydrochloride (Bay65-1942)

Catalog No.: PC-45915Not For Human Use, Lab Use Only.

Bay 65-1942 hydrochloride is a potent, selective, ATP-competitive inhibitor of IKKβ kinase with Ki of 2 nM.

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5 mg	$138	In stock
10 mg	$218	In stock
25 mg	$388	In stock
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Biological Activity

Bay 65-1942 hydrochloride is a potent, selective, ATP-competitive inhibitor of IKKβ kinase with Ki of 2 nM.
Bay 65-1942 dispalys >50-fold selectivity over IKK-α, does not inhibit (IC50>10 uM) IKK3, MKK4, MKK7, ERK-1, Syk, Lck, Fyn, PI3Kγ, PKA, and PKC.
Bay 65-1942 inhibits stress-induced NF-kappaB transactivation, chemokine-, cytokine-, and adhesion molecule expression, and T- and B-cell proliferation.
Bay 65-1942 inhibits cockroach allergen-induced airway inflammation and hyperreactivity and efficiently abrogates leukocyte trafficking induced by carrageenan in mice.

Physicochemical Properties

M.Wt	431.9125
Formula	C22H26ClN3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2H-Pyrido[2,3-d][1,3]oxazin-2-one, 7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-, hydrochloride (1:1)

References

1. Noha SM, et al. Bioorg Med Chem Lett. 2011 Jan 1;21(1):577-83.

2. Ziegelbauer K, et al. Br J Pharmacol. 2005 May;145(2):178-92.

3. Moss NC, et al. Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2248-53.

Bay 65-1942 hydrochloride (Bay65-1942)

Biological Activity

Physicochemical Properties

References

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