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Chemical Structure : Bay 65-1942 hydrochloride
CAS No.: 600734-06-3
Catalog No.: PC-45915Not For Human Use, Lab Use Only.
A potent, selective, ATP-competitive inhibitor of IKKβ kinase with Ki of 2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $312 | In stock | |
| 10 mg | $560 | In stock |
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A potent, selective, ATP-competitive inhibitor of IKKβ kinase with Ki of 2 nM; dispalys >50-fold selectivity over IKK-α, does not inhibit (IC50>10 uM) IKK3, MKK4, MKK7, ERK-1, Syk, Lck, Fyn, PI3Kγ, PKA, and PKC; inhibits stress-induced NF-kappaB transactivation, chemokine-, cytokine-, and adhesion molecule expression, and T- and B-cell proliferation; inhibits cockroach allergen-induced airway inflammation and hyperreactivity and efficiently abrogates leukocyte trafficking induced by carrageenan in mice.
| M.Wt | 431.9125 | |
| Formula | C22H26ClN3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2H-Pyrido[2,3-d][1,3]oxazin-2-one, 7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-, hydrochloride (1:1) |
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1. Noha SM, et al. Bioorg Med Chem Lett. 2011 Jan 1;21(1):577-83.
2. Ziegelbauer K, et al. Br J Pharmacol. 2005 May;145(2):178-92.
3. Moss NC, et al. Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2248-53.
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