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Benfotiamine

Chemical Structure : Benfotiamine

CAS No.: 22457-89-2

Benfotiamine (S-Benzoylthiamine O-monophosphate)

Catalog No.: PC-45197Not For Human Use, Lab Use Only.

Benfotiamine is a synthetic S-acyl derivative of thiamine (vitamin B1) that possesses anti-inflammatory effects, upregulates antioxidative system in activated BV-2 microglia cells.

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Biological Activity

Benfotiamine is a synthetic S-acyl derivative of thiamine (vitamin B1) that possesses anti-inflammatory effects, upregulates antioxidative system in activated BV-2 microglia cells.
Benfotiamine significantly improves the cognitive abilities of mild to moderate AD patients independently of brain amyloid accumulation.

Physicochemical Properties

M.Wt 466.4479
Formula C19H23N4O6PS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzenecarbothioic acid, S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propen-1-yl] ester

References

1. Bozic I, et al. Front Cell Neurosci. 2015 Sep 4;9:351.

2. Pan X, et al. Neurosci Bull. 2016 Dec;32(6):591-596.

3. Bozic I, et al. PLoS One. 2015 Feb 19;10(2):e0118372.

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