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Berberine chloride

Chemical Structure : Berberine chloride

CAS No.: 633-65-8

Berberine chloride

Catalog No.: PC-26670Not For Human Use, Lab Use Only.

Berberine chloride is an alkaloid with antibiotic properties, induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase, also directly binds to transcription factor Early B Cell Factor 2 (EBF2), modulate EBF2 phase separation and thermogenic function, also is a potent USP22 inhibitor, effectively suppresses Wnt pathway activation and CRC cell proliferation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Berberine chloride is an alkaloid with antibiotic properties, induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase, also directly binds to transcription factor Early B Cell Factor 2 (EBF2), modulate EBF2 phase separation and thermogenic function, also is a potent USP22 inhibitor, effectively suppresses Wnt pathway activation and CRC cell proliferation.

Physicochemical Properties

M.Wt 371.82
Formula C20H18ClNO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium chloride

References

1. Wang X, et al. Nat Commun. 2026 Apr 23. doi: 10.1038/s41467-026-72233-x.

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