Berberine chloride hydrate

Chemical Structure : Berberine chloride hydrate

CAS No.: 68030-18-2

Catalog No.: PC-26656Not For Human Use, Lab Use Only.

Berberine chloride hydrate (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase, disrupts G-quadruplex (G4)-STAT1 interaction and synergizes with olaparib to drive cancer cell death, shows antineoplastic properties, also is a potent USP22 inhibitor, effectively suppresses Wnt pathway activation and CRC cell proliferation.

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500 mg	$78	In stock
1 g	$118	In stock
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Biological Activity

Physicochemical Properties

M.Wt	389.83
Formula	C20H20ClNO5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium chloride hydrate

References

1. Cai Y, et al. Berberine inhibits the growth of human colorectal adenocarcinoma in vitro and in vivo. J Nat Med. 2014 Jan;68(1):53-62.

2. Wang Y, et al. Nucleic Acids Res. 2026 May 5;54(9):gkag383.

3. Gang Xu, et al. Phytomedicine. 2026 Mar:152:157765.