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Chemical Structure : Bizine
Catalog No.: PC-62871Not For Human Use, Lab Use Only.
Bizine is a phenelzine analog that inhibits LSD1 with Ki of 59 nM, displays 23-fold, 63-fold, and >100-fold selectivity for LSD-1 over MAOA, MAOB, and LSD2 respectively.
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Bizine is a phenelzine analog that inhibits LSD1 with Ki of 59 nM, displays 23-fold, 63-fold, and >100-fold selectivity for LSD-1 over MAOA, MAOB, and LSD2 respectively.
Bizine induces bulk histone H3 lysine 4 dimethylation in LNCaP cancer cells (EC50=2 uM).
Bizine protects neurons exposed to oxidative stress at 0.5 uM.
| M.Wt | 297.402 | |
| Formula | C18H23N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Prusevich P, et al. ACS Chem Biol. 2014 Jun 20;9(6):1284-93.
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