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Blebbistatin S enantiomer

Chemical Structure : Blebbistatin S enantiomer

CAS No.: 856925-71-8

Blebbistatin S enantiomer ((S)-(-)-Blebbistatin)

Catalog No.: PC-43535Not For Human Use, Lab Use Only.

Blebbistatin S enantiomer ((S)-(-)-Blebbistatin) is the S enantiomer of blebbistatin, which is a potent and selective myosin II inhibitor with IC50 of 0.5-5 uM.

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Biological Activity

Blebbistatin S enantiomer ((S)-(-)-Blebbistatin) is the S enantiomer of blebbistatin, which is a potent and selective myosin II inhibitor with IC50 of 0.5-5 uM; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly, inhibits pancreatic adenocarcinoma cellular invasiveness; inhibits some myosin II-independent processes and that blebbistatin inhibits other activities in the absence of myosin II.

Physicochemical Properties

M.Wt 292.3318
Formula C18H16N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 5.2 mg/mL (Need ultrasonic and warming)

Chemical Name/SMILES

4H-Pyrrolo[2,3-b]quinolin-4-one, 1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-1-phenyl-, (3aS)-

References

1. Straight AF, et al. Science. 2003 Mar 14;299(5613):1743-7.

2. Abe M, et al. J Biol Chem. 2003 Nov 28;278(48):47707-12.

3. Duxbury MS, et al. Biochem Biophys Res Commun. 2004 Jan 23;313(4):992-7.

4. Shu S, et al. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1472-7.

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