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Bleximenib

Chemical Structure : Bleximenib

CAS No.: 2654081-35-1

Bleximenib

Catalog No.: PC-21973Not For Human Use, Lab Use Only.

Bleximenib is a potent, selective menin/MLL protein/protein interaction inhibitor, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN); and diabetes.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Bleximenib is a potent, selective menin/MLL protein/protein interaction inhibitor, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN); and diabetes.

Physicochemical Properties

M.Wt 599.80
Formula C32H50FN7O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-N-ethyl-5-fluoro-N-isopropyl-2-((5-(2-(6-((2-methoxyethyl)(methyl)amino)-2-methylhexan-3-yl)-2,6-diazaspiro[3.4]octan-6-yl)-1,2,4-triazin-6-yl)oxy)benzamide

References

1. Patent WO2022237720, compound A.

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