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Bm-MPK1-IN-15b

Chemical Structure : Bm-MPK1-IN-15b

CAS No.: 2222294-62-2

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Bm-MPK1-IN-15b

Catalog No.: PC-63332Not For Human Use, Lab Use Only.

Bm-MPK1-IN-15b is a potent, orally bioavailable inhibitor of B. malayi stress-activated kinase Bm-MPK1 with IC50 of 24 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Bm-MPK1-IN-15b is a potent, orally bioavailable inhibitor of B. malayi stress-activated kinase Bm-MPK1 with IC50 of 24 nM; inhibits human p38α and JNK3 with IC50 of 26 and 170 nM, respectively; reduces the motility of adult worms at 100 nM, Bm-MPK1-IN-15b is a tool compound for in vivo studies aimed at strengthening the role of Bm MPK1 in B. malayi response to host oxidative stress.

    Physicochemical Properties

    M.Wt 391.475
    Formula C22H25N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((1r,4r)-4-((4-(5-methyl-3-phenylisoxazol-4-yl)pyrimidin-2-yl)amino)cyclohexyl)acetamide

    References

    1. Tummalapalli SR, et al. ACS Med Chem Lett. 2018 Feb 9;9(3):210-214.

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