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Bobcat339

Chemical Structure : Bobcat339

CAS No.: 2280037-51-4

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Bobcat339 (Bobcat 339)

Catalog No.: PC-36114Not For Human Use, Lab Use Only.

Bobcat339 (Bobcat 339) is a novel cytosine-based TET enzyme inhibitor with IC50 of 33 uM (TET1) and 73 uM (TET2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.

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10 mg $88 In stock
25 mg $138 In stock
50 mg $218 In stock
100 mg $368 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Bobcat339 (Bobcat 339) is a novel cytosine-based TET enzyme inhibitor with IC50 of 33 uM (TET1) and 73 uM (TET2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.
Bobcat339 is a useful tool for investigation of epigenetics and serve as a starting point for new therapeutics that target DNA methylation and gene transcription.

Physicochemical Properties

M.Wt 297.742
Formula C16H12ClN3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-([1,1'-biphenyl]-3-yl)-4-amino-5-chloropyrimidin-2(1H)-one

References

1. Chua GNL, et al. ACS Med Chem Lett. 2019 Jan 31;10(2):180-185.

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