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Chemical Structure : Bortezomib
CAS No.: 179324-69-7
Catalog No.: PC-42470Not For Human Use, Lab Use Only.
Bortezomib (PS341) is a potent, selective, competitive, orally active Proteasome inhibitor with Ki of 0.6 nM for 20S Proteasome.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $58 | In stock | |
| 25 mg | $98 | In stock | |
| 50 mg | $158 | In stock | |
| 100 mg | $238 | In stock | |
| 250 mg | Get quote |
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Bortezomib (PS341) is a potent, selective, competitive, orally active Proteasome inhibitor with Ki of 0.6 nM for 20S Proteasome.
Bortezomib (PS341) shows only modest activity toward serine and thiol proteases (cathepsin G, elastase, chymotrypsin Ki>300 nM).
Bortezomib (PS341) inhibits the TNFα-stimulated activation of NF-κB in primary HUVE cells (IC50=0.5 uM) by blocking the degradation of the inhibitor IκBα.
Bortezomib (PS341) exhibits anti-inflammatory effects in vivo.
| M.Wt | 384.2372 | |
| Formula | C19H25BN4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Boronic acid, B-[(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]- |
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1. Palombella VJ, et al. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15671-6.
2. Frankel A, et al. Clin Cancer Res. 2000 Sep;6(9):3719-28.
3. Teicher BA, et al. Clin Cancer Res. 1999 Sep;5(9):2638-45.
4. Adams J, et al. Bioorg Med Chem Lett. 1998 Feb 17;8(4):333-8.
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