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Cat. No. Product Name Information
PC-22005

Davelizomib

Proteasome inhibitor

Davelizomib is a proteasome inhibitor with antineoplastic effect.
PC-21188

TCL-1

Rpn-13 inhibitor

TCL-1 is non-covalent inhibitor of the Pru (Pleckstrin-like receptor for ubiquitin) domain of Rpn-13, affects proteasome-mediated proteolysis.
PC-49521

WZ-1831

β5c inhibitor

WZ-1831 is a potent and highly selective inhibitor of human constitutive proteasome chymotryptic activity (β5c) with IC50 of 10 nM, >500-fold selectivity over β5i (IC50=7.1 uM).
PC-49415

Compound 14-100

Hsp70 inhibitor

Compound 14-100 is a small molecule, orally active inhibitor targeting pancreatic cancer cell chemotaxis in vitro and in vivo, inhibits Hsp70 coding genes.
PC-47062

TXS-8

Rpn6 binder

TXS-8 is a specific, small molecule binder of Rpn-6 with KD of 14 uM, Rpn-6 is a subunit of the 19S regulatory particle (RP) of 26s proteasome.
PC-38434

Zetomipzomib

LMP7/LMP2 inhibitor

Zetomipzomib (KZR-616) is a first-in-class inhibitor of immunoproteasome, dually inhibits immunoproteasome subunits LMP7 (IC50, 39/57 nM, hLMP7/mLMP7) and LMP2 (IC50, 131/179 nM, hLMP2/mLMP2).
PC-72569

CBK006377

UPS inhibitor

CBK006377 (CBK77) is a small molecule inhibitor of the ubiquitin-proteasome system (UPS) with EC50 of 4.3 uM in MelJuSo Ub-YFP cells (6h treatment).
PC-72402

M3258

LMP7 inhibitor

M3258 (M 3258) is a potent, reversible, highly selective and orally acitve LMP7 inhibitor with cellular IC50 of 4.1 nM.
PC-35491

TCH-165

Proteasome modulator

TCH-165 is a specific small molecule modulator of proteasome assembly, regulates the dynamic equilibrium between the 20S and 26S proteasome complexes, favoring 20S-mediated protein degradation.
PC-43439

MG-132

Proteasome inhibitor

MG-132 (Z-Leu-leu-leu-al, Zlllal) is a potent, reversible, and cell-permeable proteasome inhibitor with IC50 of 0.1 and 1.2 μM for the inhibition of proteasome and calpain, respectively.
PC-43393

ONX-0914

LMP7 inhibitor

ONX-0914 (PR-957) is a potent, selective inhibitor of the chymotrypsin-like subunit of immunoproteasome LMP7 with IC80 <100 nM, 20- to 40-fold more selective over β5 or LMP2.
PC-43371

Celastrol

PRDX1 inhibitor, 20S proteasome inhibitor

Celastrol (Tripterin) is an active compound extracted from Chinese medicine Thunder of God Vine, is a potent proteasome inhibitor, preferentially inhibits the chymotrypsin-like activity of 20S proteasome with IC50 of 2.5 uM.

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