| Cat. No. |
Product Name |
Information |
| PC-60963 |
PR-924
LMP7 inhibitor
|
PR-924 is a potent, specific immunoproteasome LMP7 subunit inhibitor with IC50 of 25 nM, >100-fold selectivity over β5c, β1i, β1c, β2i and β2c subunits (IC50>3 uM). |
| PC-60962 |
KZR-504
LMP2 inhibitor
|
KZR-504 (KZR504) is a potent, highly selective inhibitor of immunoproteasome low molecular polypeptide-2 (LMP2) subunit with IC50 of 51 nM. |
| PC-60898 |
Capzimin
Rpn11 inhibitor
|
Capzimin (Rpn11 inhibitor 3027) is a derivative of 8TQ, and potent and specific inhibitor of proteasome isopeptidase Rpn11 (PSMD14) with IC50 of 0.34 uM, >7-fold improved potency over 8TQ (quinoline-8-thiol). |
| PC-60476 |
FV-162
Proteasome inhibitor
|
FV-162 is a potent, orally bioavailable, irreversible proteasome inhibitor with potent antimyeloma activity (IC50<60 nM). |
| PC-42596 |
Ixazomib
Proteasome inhibitor
|
Ixazomib (MLN2238) is a potent, selective, orally bioavailable proteasome inhibitor with IC50 of 3.4 nM. |
| PC-42595 |
MLN9708
Proteasome inhibitor
|
Ixazomib citrate (MLN9708) is a potent, selective, orally bioavailable proteasome inhibitor with IC50 of 3.4 nM. |
| PC-42470 |
Bortezomib
|
Bortezomib (PS-341) is a potent, selective, competitive, orally active Proteasome inhibitor with Ki of 0.6 nM for 20S Proteasome. |
| PC-42597 |
Delanzomib
Proteasome inhibitor
|
Delanzomib (CEP18770) is a potent, orally active proteasome inhibitor with IC50 of 3.8 nM against chymotrypsin-like proteasome activity. |
| PC-42598 |
Carfilzomib
Proteasome inhibitor
|
Carfilzomib (PR-171) is a potent, highly selective inhibitor chymotrypsin-like activity of proteasome with IC50 of 6 nM. |
| PC-45547 |
VR23
Proteasome inhibitor
|
VR23 is a potent inhibitor of trypsin-like proteasome (IC50=1 nM), chymotrypsin-like proteasome (IC50=50-100 nM) and caspase-like proteasome (IC50=3 uM). |
| PC-42242 |
RA190
Rpn13 inhibitor
|
RA190 (RA-190) is a reversible, highly selective, orally active inhibitor of the proteasomal ubiquitin receptor Rpn13, exhibits potent anti-proliferative effects against MM lines (IC50<0.1 uM) and HPV-transformed cells (IC50<0.3 uM). |
| PC-22711 |
Up284
Rpn13 inhibitor
|
Up284 is a small molecule inhibitor of proteasome's 19S Regulatory Particle (RP) ubiquitin receptor RPN13 (ADRM1, hRPN13, or GP110), covalently binds RPN13 and induces rapid apoptosis in ovarian cancer cells. |
