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Cat. No. Product Name Information
PC-49521

WZ-1831

β5c inhibitor

WZ-1831 is a potent and highly selective inhibitor of human constitutive proteasome chymotryptic activity (β5c) with IC50 of 10 nM, >500-fold selectivity over β5i (IC50=7.1 uM).
PC-38434

Zetomipzomib

LMP7/LMP2 inhibitor

Zetomipzomib (KZR-616) is a first-in-class inhibitor of immunoproteasome, dually inhibits immunoproteasome subunits LMP7 (IC50, 39/57 nM, hLMP7/mLMP7) and LMP2 (IC50, 131/179 nM, hLMP2/mLMP2).
PC-72569

CBK006377

UPS inhibitor

CBK006377 (CBK77) is a small molecule inhibitor of the ubiquitin-proteasome system (UPS) with EC50 of 4.3 uM in MelJuSo Ub-YFP cells (6h treatment).
PC-43371

Celastrol

Celastrol (Tripterin) is an active compound extracted from Chinese medicine Thunder of God Vine, is a potent proteasome inhibitor, preferentially inhibits the chymotrypsin-like activity of 20S proteasome with IC50 of 2.5 uM.
PC-42948

PI-1840

PI-1840 is a potent, selective, noncovalent, reversible inhibitor for proteasome chymotrypsin-like (CT-L) activity with IC50 of 27 nM, shows no effect on trypsin-like and peptidylglutamyl peptide hydrolyzing activities (IC50>100 uM).
PC-42896

Oprozomib

Oprozomib (ONX-0912.
PC-61315

Marizomib

A potent, orally bioactive 20S proteasome inhibitor with IC50 of 1.3 nM (inhibition of proteasomal chymotrypsin-like proteolytic activity).
PC-61314

Omuralide

A potent 20S proteasome inhibitor with IC50 of 49 nM (inhibition of proteasomal chymotrypsin-like proteolytic activity)..
PC-61131

8-Thioquinoline

A potent, small molecule inhibitor of the proteasome subunit Rpn11 with IC50 of 2.5 uM..
PC-60971

YU-101

A potent, specific proteasome β5 subunit inhibitor with IC50 of 0.26 uM, 7.3 and 17.3-fold selectivity over β2i and β1i subunit, respecitvely..
PC-60970

NC-005

A potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 44 nM, 105 and 225-fold selectivity over β2i and β1i subunit, respecitvely.
PC-60966

UK-101

A potent, specific immunoproteasome β1i (LMP2) subunit inhibitor with IC50 of 104 nM, 144- and 10-fold selectivity over β1c and β5 subunit respectivey.

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