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Chemical Structure : KZR-504
CAS No.: 1629052-78-3
Catalog No.: PC-60962Not For Human Use, Lab Use Only.
KZR-504 (KZR504) is a potent, highly selective inhibitor of immunoproteasome low molecular polypeptide-2 (LMP2) subunit with IC50 of 51 nM.
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|---|---|---|---|
| 5 mg | $388 | In stock | |
| 10 mg | $598 | In stock | |
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KZR-504 (KZR504) is a potent, highly selective inhibitor of immunoproteasome low molecular polypeptide-2 (LMP2) subunit with IC50 of 51 nM.
KZR-504 displays >100-fold selectivity over β1, LMP7, β5, MECL1 and β2 subunits.
KZR-504 shows little to no effect on cytokine production in human peripheral blood mononuclear cells (PBMCs) stimulated with LPS, and can be administered at a selective dose in vivo.
| M.Wt | 413.43 | |
| Formula | C21H23N3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-((S)-3-hydroxy-1-(((S)-1-((S)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)-6-oxo-1,6-dihydropyridine-2-carboxamide |
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1. Johnson HWB, et al. ACS Med Chem Lett. 2017 Mar 9;8(4):413-417.
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