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NC-001

Chemical Structure : NC-001

CAS No.: 1237540-68-9

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NC-001 (NC001, az-NC-001)

Catalog No.: PC-60969Not For Human Use, Lab Use Only.

NC-001 (NC 001, NC001, az-NC-001) is a potent, specific, cell-permeable inhibitor of immunoproteasome caspase-like sites (β1i and β1), does not correlate with inhibition of chymotrypsin-like sites.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NC-001 (NC 001, NC001, az-NC-001) is a potent, specific, cell-permeable inhibitor of immunoproteasome caspase-like sites (β1i and β1), does not correlate with inhibition of chymotrypsin-like sites.

    Physicochemical Properties

    M.Wt 535.646
    Formula C25H41N7O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-1-((2-azidoacetyl)-L-alanyl)-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxohexan-2-yl)pyrrolidine-2-carboxamide

    References

    1. Britton M, et al. Chem Biol. 2009 Dec 24;16(12):1278-89.

    2. de Bruin G, et al. J Med Chem. 2014 Jul 24;57(14):6197-209.

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