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Chemical Structure : PR-924
Catalog No.: PC-60963Not For Human Use, Lab Use Only.
PR-924 is a potent, specific immunoproteasome LMP7 subunit inhibitor with IC50 of 25 nM, >100-fold selectivity over β5c, β1i, β1c, β2i and β2c subunits (IC50>3 uM).
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PR-924 is a potent, specific immunoproteasome LMP7 subunit inhibitor with IC50 of 25 nM, >100-fold selectivity over β5c, β1i, β1c, β2i and β2c subunits (IC50>3 uM).
PR-924 shows weak activity toward LMP2 and no detectable activity toward β1, β2, or MECL1.
| M.Wt | 618.734 | |
| Formula | C37H38N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Parlati F, et al. Blood. 2009 Oct 15;114(16):3439-47.
2. de Bruin G, et al. J Med Chem. 2014 Jul 24;57(14):6197-209.
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