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Ixazomib

Chemical Structure : Ixazomib

CAS No.: 1072833-77-2

Ixazomib (MLN2238, MLN-2238)

Catalog No.: PC-42596Not For Human Use, Lab Use Only.

Ixazomib (MLN2238) is a potent, selective, orally bioavailable proteasome inhibitor with IC50 of 3.4 nM.

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Biological Activity

Ixazomib (MLN2238) is a potent, selective, orally bioavailable proteasome inhibitor with IC50 of 3.4 nM.
Ixazomib binds to and inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with Ki of 0.93 nM, weakly inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites (IC50 of 31 and 3,500 n M).
Ixazomib inhibits growth and induces apoptosis in MM cells.
Ixazomib shows improved antitumor activity in models of lymphoma compared with bortezomib.

Physicochemical Properties

M.Wt 361.0287
Formula C14H19BCl2N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 28 mg/mL

Chemical Name/SMILES

Boronic acid, B-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-

References

1. Kupperman E, et al. Cancer Res. 2010 Mar 1;70(5):1970-80.

2. Chauhan D, et al. Clin Cancer Res. 2011 Aug 15;17(16):5311-21.

3. Lee EC, et al. Clin Cancer Res. 2011 Dec 1;17(23):7313-23.

4. Tian Z, et al. Blood. 2012 Nov 8;120(19):3958-67.

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