Catalog No.: PC-60966Not For Human Use, Lab Use Only.
UK-101 is a potent, specific immunoproteasome β1i (LMP2) subunit inhibitor with IC50 of 104 nM, 144- and 10-fold selectivity over β1c and β5 subunit respectivey.
UK-101 is a potent, specific immunoproteasome β1i (LMP2) subunit inhibitor with IC50 of 104 nM, 144- and 10-fold selectivity over β1c and β5 subunit respectivey.
UK-101 induces apoptosis of PC-3 cells and results in significant inhibition (~50-60%) of tumour growth in vivo.
UK-101 does not block degradation of IκBα in PC-3 cells treated with TNF-α.
