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Chemical Structure : UK-101
CAS No.: 1000313-40-5
Catalog No.: PC-60966Not For Human Use, Lab Use Only.
UK-101 is a potent, specific immunoproteasome β1i (LMP2) subunit inhibitor with IC50 of 104 nM, 144- and 10-fold selectivity over β1c and β5 subunit respectivey.
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UK-101 is a potent, specific immunoproteasome β1i (LMP2) subunit inhibitor with IC50 of 104 nM, 144- and 10-fold selectivity over β1c and β5 subunit respectivey.
UK-101 induces apoptosis of PC-3 cells and results in significant inhibition (~50-60%) of tumour growth in vivo.
UK-101 does not block degradation of IκBα in PC-3 cells treated with TNF-α.
| M.Wt | 484.753 | |
| Formula | C25H48N2O5Si | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-((S)-1-(((S)-1-((S)-2-(((tert-butyldimethylsilyl)oxy)methyl)oxiran-2-yl)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopropan-2-yl)heptanamide |
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1. de Bruin G, et al. J Med Chem. 2014 Jul 24;57(14):6197-209.
2. Wehenkel M, et al. Br J Cancer. 2012 Jun 26;107(1):53-62.
3. Lei B, et al. J Phys Chem B. 2010 Sep 30;114(38):12333-9.
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