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MLN9708

Chemical Structure : MLN9708

CAS No.: 1239908-20-3

MLN9708 (Ixazomib citrate;MLN 9708;MLN-9708)

Catalog No.: PC-42595Not For Human Use, Lab Use Only.

Ixazomib citrate (MLN9708) is a potent, selective, orally bioavailable proteasome inhibitor with IC50 of 3.4 nM.

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Biological Activity

Ixazomib citrate (MLN9708) is a potent, selective, orally bioavailable proteasome inhibitor with IC50 of 3.4 nM.
Ixazomib citrate (MLN9708) binds to and inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with Ki of 0.93 nM, weakly inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites (IC50 of 31 and 3,500 n M).
Ixazomib citrate (MLN9708) inhibits growth and induces apoptosis in MM cells.
Ixazomib citrate (MLN9708) shows improved antitumor activity in models of lymphoma compared with bortezomib.

Physicochemical Properties

M.Wt 517.1216
Formula C20H23BCl2N2O9
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,3,2-Dioxaborolane-4,4-diacetic acid, 2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-5-oxo-

References

1. Kupperman E, et al. Cancer Res. 2010 Mar 1;70(5):1970-80.

2. Chauhan D, et al. Clin Cancer Res. 2011 Aug 15;17(16):5311-21.

3. Lee EC, et al. Clin Cancer Res. 2011 Dec 1;17(23):7313-23.

4. Tian Z, et al. Blood. 2012 Nov 8;120(19):3958-67.

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