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ML 604440

Chemical Structure : ML 604440

CAS No.: 1140517-08-3

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ML 604440 (ML604440;ML-604440)

Catalog No.: PC-60968Not For Human Use, Lab Use Only.

ML 604440 (ML604440, ML-604440) is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor.

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5 mg $288 In stock
10 mg $458 In stock
25 mg $758 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ML 604440 (ML604440, ML-604440) is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor.
ML 604440 reduces the cleavage of Ac-PAL-AMC by proteasomes from WT mice in a dose-dependent manner (12.5-200 nM), with no affect on β5/LMP7.

Physicochemical Properties

M.Wt 388.194
Formula C17H24BF3N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-(3-methyl-1-(2-methyl-2-(2-(trifluoromethyl)benzamido)propanamido)butyl)boronic acid

References

1. de Bruin G, et al. J Med Chem. 2014 Jul 24;57(14):6197-209.

2. Basler M, et al. J Immunol. 2012 Aug 15;189(4):1868-77.

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