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PR-893

Chemical Structure : PR-893

CAS No.: 1426305-23-8

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PR-893 (PR 893, PR893, CPSI)

Catalog No.: PC-60964Not For Human Use, Lab Use Only.

PR-893 is a potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 17 nM, 21-fold and 13-fold selectivity for β5 over LMP7 and LMP2 subunits, respecitvely.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PR-893 is a potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 17 nM, 21-fold and 13-fold selectivity for β5 over LMP7 and LMP2 subunits, respecitvely.

    Physicochemical Properties

    M.Wt 478.546
    Formula C23H34N4O7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((S)-1-(((S)-1-cyclopropyl-2-(((S)-4-methyl-1-((S)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-2-oxoethyl)amino)-3-methoxy-1-oxopropan-2-yl)-5-methylisoxazole-3-carboxamide

    References

    1. Parlati F, et al. Blood. 2009 Oct 15;114(16):3439-47.

    2. de Bruin G, et al. J Med Chem. 2014 Jul 24;57(14):6197-209.

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