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FV-162

Chemical Structure : FV-162

CAS No.: 1565822-28-7

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FV-162 (FV 162, FV162)

Catalog No.: PC-60476Not For Human Use, Lab Use Only.

FV-162 is a potent, orally bioavailable, irreversible proteasome inhibitor with potent antimyeloma activity (IC50<60 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    FV-162 is a potent, orally bioavailable, irreversible proteasome inhibitor with potent antimyeloma activity (IC50<60 nM).
    FV-162  induces rapid, irreversible inhibition of chymotrypsin-like proteasome activity in murine red blood cells and inhibits tumor growth in myeloma xenograft model.

    Physicochemical Properties

    M.Wt 604.574
    Formula C25H28F4N4O7S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((S)-3-(difluoromethoxy)-1-(((S)-3-(difluoromethoxy)-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)-2-methylthiazole-5-carboxamide

    References

    1. Wang Z, et al. Cell Death Dis. 2015 Jul 9;6:e1815.

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