| Cat. No. |
Product Name |
Information |
| PC-45547 |
VR23
Proteasome inhibitor
|
VR23 is a potent inhibitor of trypsin-like proteasome (IC50=1 nM), chymotrypsin-like proteasome (IC50=50-100 nM) and caspase-like proteasome (IC50=3 uM). |
| PC-42242 |
RA190
Rpn13 inhibitor
|
RA190 (RA-190) is a reversible, highly selective, orally active inhibitor of the proteasomal ubiquitin receptor Rpn13, exhibits potent anti-proliferative effects against MM lines (IC50<0.1 uM) and HPV-transformed cells (IC50<0.3 uM). |
| PC-22711 |
Up284
Rpn13 inhibitor
|
Up284 is a small molecule inhibitor of proteasome's 19S Regulatory Particle (RP) ubiquitin receptor RPN13 (ADRM1, hRPN13, or GP110), covalently binds RPN13 and induces rapid apoptosis in ovarian cancer cells. |
| PC-22710 |
RA475
Rpn13 inhibitor
|
RA475 is a small molecule inhibitor of proteasome's 19S Regulatory Particle (RP) ubiquitin receptor RPN13 (ADRM1, hRPN13, or GP110), binds to RPN13 and induces rapid apoptosis in ovarian cancer cells. |
| PC-22652 |
FHND6091
Proteasome inhibitor
|
FHND6091 is the prodrug of FHND6081, which is a potent, selective oral proteasome inhibitor, binds irreversibly to the β5 submit of the 20S proteasome and exerts anti-cancer activities. |
| PC-22651 |
FHND6081
Proteasome inhibitor
|
FHND6081 is a potent, selective oral proteasome inhibitor, binds irreversibly to the β5 submit of the 20S proteasome and exerts anti-cancer activities. |
| PC-22061 |
hRpn13 inhibitor XL44
hRpn13 inhibitor
|
XL44 is a potent, specific hRpn13 (proteasome subunit hRpn13)-binding compound, binds to hRpn13 Pru domain, induces loss of hRpn13 Pru and hRpn13-dependent apoptosis. |
| PC-21916 |
Epoxomicin
Proteasome inhibitor
|
Epoxomicin (BU-4061T) is a potent, selective and irreversible proteasome inhibitor, covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the proteasome and potently inhibits primarily the chymotrypsin-like activity. |
| PC-21189 |
TCL-Ester
Rpn-13 inhibitor
|
TCL-Ester is the cell-permeable derivative of TCL-1, a non-covalent ligand targeting the Pru domain of Rpn-13. |
| PC-21187 |
KDT-11
Rpn-13 inhibitor
|
KDT-11 is a specific, reversible peptidomimetic binder inhibitor of Rpn-13 with binding KD of 3 uM, selectively inhibit proliferation of a broad range of cancer cell lines (NCI60, IC50=5 uM), but not non-malignant cells. |
| PC-20757 |
BT317
LonP1 inhibitor
|
BT317 is a small molecule dual inhibitor of mitochondrial Lon Peptidase 1 (LonP1) and CT-L proteasome, subsequently induces ROS accumulation and autophagy-dependent cell death in high-grade IDH1 mutated astrocytoma lines. |
