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RA475

Chemical Structure : RA475

CAS No.: 2750008-05-8

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RA475 (RA-475)

Catalog No.: PC-22710Not For Human Use, Lab Use Only.

RA475 is a small molecule inhibitor of proteasome's 19S Regulatory Particle (RP) ubiquitin receptor RPN13 (ADRM1, hRPN13, or GP110), binds to RPN13 and induces rapid apoptosis in ovarian cancer cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

RA475 is a small molecule inhibitor of proteasome's 19S Regulatory Particle (RP) ubiquitin receptor RPN13 (ADRM1, hRPN13, or GP110), binds to RPN13 and induces rapid apoptosis in ovarian cancer cells.
RA475 cytotoxicity is mildly synergistic with cisplatin
RA475 (0.5 μM and 1 μM) induces accumulation of very high molecular weight polyubiquitinated proteins in SKOV3 cells.
RA475 stabilizes proteasome reporter protein 4UbFL in vitro and in vivo.
RA475 profoundly inhibits the intraperitoneal growth of the ID8-luciferase ovarian tumor model. 

Physicochemical Properties

M.Wt 407.48
Formula C25H21N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,3-bis((E)-4-cyanobenzylidene)-2-oxo-7-azaspiro[3.5]nonane-7-carboximidamide

References

1. Ravi K Anchoori, et al. PLoS One. 2024 Jul 11;19(7):e0305710.

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