Chemical Structure : Lactacystin
CAS No.: 133343-34-7
Catalog No.: PC-24468Not For Human Use, Lab Use Only.
Lactacystin is a potent, orally active, irreversible, cell-permeable, specific proteasome inhibitor (IC50=4.8 uM), also inhibits the lysosomal enzyme cathepsin A, inhibits cell cycle progression and induces neurite outgrowth in murine neuroblastoma cell line.
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Lactacystin is a potent, orally active, irreversible, cell-permeable, specific proteasome inhibitor (IC50=4.8 uM), also inhibits the lysosomal enzyme cathepsin A, inhibits cell cycle progression and induces neurite outgrowth in murine neuroblastoma cell line.
| M.Wt | 376.42 | |
| Formula | C15H24N2O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-Acetyl-S-((2R,3S,4R)-3-hydroxy-2-((S)-1-hydroxy-2-methylpropyl)-4-methyl-5-oxopyrrolidine-2-carbonyl)-L-cysteine |
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1. Omura S, et al. J Antibiot (Tokyo). 1991 Jan;44(1):113-6.
2. Oda K, et al. Biochem Biophys Res Commun. 1996 Feb 27;219(3):800-5.
3. Fenteany G, et al. Science. 1995 May 5;268(5211):726-31.

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