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Chemical Structure : RA190
CAS No.: 1617495-03-0
Catalog No.: PC-42242Not For Human Use, Lab Use Only.
RA190 (RA-190) is a reversible, highly selective, orally active inhibitor of the proteasomal ubiquitin receptor Rpn13, exhibits potent anti-proliferative effects against MM lines (IC50<0.1 uM) and HPV-transformed cells (IC50<0.3 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $178 | In stock | |
| 25 mg | $328 | In stock | |
| 100 mg | $868 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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RA190 (RA-190) is a reversible, highly selective, orally active inhibitor of the proteasomal ubiquitin receptor Rpn13, exhibits potent anti-proliferative effects against MM lines (IC50<0.1 uM) and HPV-transformed cells (IC50<0.3 uM).
RA190 is a bis-benzylidine piperidone that covalently binds to Cys 88 of ubiquitin receptor RPN13 in the 19S regulatory particle and inhibits proteasome function.
RA190 inhibits proteasome function, triggering rapid accumulation of polyubiquitinated proteins.
RA190 profoundly reduced growth of MM and ovarian cancer xenografts.
| M.Wt | 596.7594 | |
| Formula | C28H23Cl5N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 10 mM |
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| Chemical Name/SMILES |
4-Piperidinone, 1-[(2S)-2-amino-1-oxo-3-phenylpropyl]-3,5-bis[(3,4-dichlorophenyl)methylene]-, hydrochloride (1:1) |
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1. Anchoori RK, et al. Cancer Cell. 2013 Dec 9;24(6):791-805.
2. Randles L, et al. J Biol Chem. 2016 Apr 15;291(16):8773-83.
3. Song Y, et al. Leukemia. 2016 Sep;30(9):1877-86.
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