Chemical Structure : Delanzomib
CAS No.: 847499-27-8
Catalog No.: PC-42597Not For Human Use, Lab Use Only.
Delanzomib (CEP18770) is a potent, orally active proteasome inhibitor with IC50 of 3.8 nM against chymotrypsin-like proteasome activity.
Packing | Price | Stock | Quantity |
---|---|---|---|
5 mg | $98 | In stock | |
10 mg | $148 | In stock | |
25 mg | $258 | In stock | |
50 mg | $428 | In stock | |
100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Delanzomib (CEP18770) is a potent, orally active proteasome inhibitor with IC50 of 3.8 nM against chymotrypsin-like proteasome activity.
Delanzomib demonstrates marginal inhibition of the tryptic and peptidyl glutamyl activities of the proteosome.
Delanzomib down-modulates the NF-kappaB activity and the expression of several NF-kappaB downstream effectors, induces apoptotic cell death in MM cells.
Delanzomib demonstrates tumor regression in MM xenografts with favorable tumor selectivity profile.
M.Wt | 413.2751 | |
Formula | C21H28BN3O5 | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
|
Chemical Name/SMILES |
Boronic acid, B-[(1R)-1-[[(2S,3R)-3-hydroxy-1-oxo-2-[[(6-phenyl-2-pyridinyl)carbonyl]amino]butyl]amino]-3-methylbutyl]- |
1. Piva R, et al. Blood. 2008 Mar 1;111(5):2765-75.
2. Sanchez E, et al. Br J Haematol. 2010 Feb;148(4):569-81.
3. Seavey MM, et al. Int Immunopharmacol. 2012 Jan;12(1):257-70.
4. Berkers CR, et al. Mol Pharm. 2012 May 7;9(5):1126-35.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright