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Chemical Structure : Carfilzomib
CAS No.: 868540-17-4
Catalog No.: PC-42598Not For Human Use, Lab Use Only.
Carfilzomib (PR-171) is a potent, highly selective inhibitor chymotrypsin-like activity of proteasome with IC50 of 6 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | $378 | In stock | |
| 250 mg | Get quote |
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Carfilzomib (PR-171) is a potent, highly selective inhibitor chymotrypsin-like activity of proteasome with IC50 of 6 nM.
Carfilzomib (PR-171) weakly inhibits caspase-like and trypsin-like activities in cellular assays (IC50150-200 nM), also inhibits the chymotrypsin-like activity of the immunoproteasome (IC50=33 nM).
Carfilzomib (PR-171) accumulates proteasome substrates and induces cell cycle arrest and/or apoptosis.
Carfilzomib (PR-171) shows antitumor efficacy in vivo.
| M.Wt | 719.9099 | |
| Formula | C40H57N5O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
L-Phenylalaninamide, (αS)-α-[[2-(4-morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]- |
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1. Kuhn DJ, et al. Blood. 2007 Nov 1;110(9):3281-90.
2. Parlati F, et al. Blood. 2009 Oct 15;114(16):3439-47.
3. O'Connor OA, et al. Clin Cancer Res. 2009 Nov 15;15(22):7085-91.
4. Demo SD, et al. Cancer Res. 2007 Jul 1;67(13):6383-91.
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