Chemical Structure : YU102
CAS No.:
344591-95-3
YU102
(YU-102)
Catalog No.: PC-27246Not For Human Use, Lab Use Only.
YU102 is a potent, selective dual inhibitor of immunoproteasome (iP) catalytic subunit LMP2 and constitutive proteasome (cP) catalytic subunit Y with IC50 of 105.2 nM (LMP2/β1i) and 206.7 nM (Y/β1), shows no activity against X/β5 and LMP7/β5i.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
YU102 is a potent, selective dual inhibitor of immunoproteasome (iP) catalytic subunit LMP2 and constitutive proteasome (cP) catalytic subunit Y with IC50 of 105.2 nM (LMP2/β1i) and 206.7 nM (Y/β1), shows no activity against X/β5 and LMP7/β5i.
YU102 ameliorates AD-related cognitive impairment in the Tg2576 mouse model
YU102 exerts its efficacy independently of Aβ deposition and tau aggregation.
YU102 reduces the numbers of activated astrocytes and microglia in Tg2576 mice.
YU102 attenuates the secretion of pro-inflammatory cytokines from microglia.
YU102 inhibits in vivo and in vitro RPE (retinal pigment epithelium) degeneration in Tg2576 mice.
YU102 has no cytotoxic effect.
Physicochemical Properties
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M.Wt
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514.62
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Formula
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C27H38N4O6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-1-(acetylglycyl)-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide
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References
1. In Jun Yeo, et al. Sci Rep. 2019 Dec 5;9(1):18393.
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