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VR23

Chemical Structure : VR23

CAS No.: 1624602-30-7

VR23 (Proteasome inhibitor VR23)

Catalog No.: PC-45547Not For Human Use, Lab Use Only.

VR23 is a potent inhibitor of trypsin-like proteasome (IC50=1 nM), chymotrypsin-like proteasome (IC50=50-100 nM) and caspase-like proteasome (IC50=3 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

VR23 is a potent inhibitor of trypsin-like proteasome (IC50=1 nM), chymotrypsin-like proteasome (IC50=50-100 nM) and caspase-like proteasome (IC50=3 uM).
VR23 targets the β2 of the 20S proteasome catalytic subunit and structurally distinct from other known proteasome inhibitors and selectively kills cancer cells by apoptosis, with little effect on noncancerous cells.

Physicochemical Properties

M.Wt 477.8782
Formula C19H16ClN5O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Quinoline, 7-chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]-

References

1. Pundir S, et al. Cancer Res. 2015 Oct 1;75(19):4164-75.

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