Catalog No.: PC-20757Not For Human Use, Lab Use Only.
BT317 is a small molecule dual inhibitor of mitochondrial Lon Peptidase 1 (LonP1) and CT-L proteasome, subsequently induces ROS accumulation and autophagy-dependent cell death in high-grade IDH1 mutated astrocytoma lines.
BT317 is a small molecule dual inhibitor of mitochondrial Lon Peptidase 1 (LonP1) and CT-L proteasome, subsequently induces ROS accumulation and autophagy-dependent cell death in high-grade IDH1 mutated astrocytoma lines.
BT317 inhibits LonP1 protease activity with IC50 of 58.15 uM.
BT317 exhibits synergy with temozolomide in autophagy-dependent cell death in IDH1 mutant malignant astrocytoma.
BT317 is selective to the tumor microenvironment and demonstrated therapeutic efficacy both as a single agent and in combination TMZ in IDH mutant astrocytoma models.
