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Chemical Structure : BT317
Catalog No.: PC-20757Not For Human Use, Lab Use Only.
BT317 is a small molecule dual inhibitor of mitochondrial Lon Peptidase 1 (LonP1) and CT-L proteasome, subsequently induces ROS accumulation and autophagy-dependent cell death in high-grade IDH1 mutated astrocytoma lines.
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BT317 is a small molecule dual inhibitor of mitochondrial Lon Peptidase 1 (LonP1) and CT-L proteasome, subsequently induces ROS accumulation and autophagy-dependent cell death in high-grade IDH1 mutated astrocytoma lines.
BT317 inhibits LonP1 protease activity with IC50 of 58.15 uM.
BT317 exhibits synergy with temozolomide in autophagy-dependent cell death in IDH1 mutant malignant astrocytoma.
BT317 is selective to the tumor microenvironment and demonstrated therapeutic efficacy both as a single agent and in combination TMZ in IDH mutant astrocytoma models.
| M.Wt | 315.71 | |
| Formula | C16H10ClNO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Douglas C, et al. bioRxiv. 2023 Apr 17:2023.04.13.536816.
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