Chemical Structure : BT317
CAS No.:
2334093-39-7
BT317
(BT 317)
Catalog No.: PC-20757Not For Human Use, Lab Use Only.
BT317 is a small molecule dual inhibitor of mitochondrial Lon Peptidase 1 (LonP1) and CT-L proteasome, subsequently induces ROS accumulation and autophagy-dependent cell death in high-grade IDH1 mutated astrocytoma lines.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BT317 is a small molecule dual inhibitor of mitochondrial Lon Peptidase 1 (LonP1) and CT-L proteasome, subsequently induces ROS accumulation and autophagy-dependent cell death in high-grade IDH1 mutated astrocytoma lines.
BT317 inhibits LonP1 protease activity with IC50 of 58.15 uM.
BT317 exhibits synergy with temozolomide in autophagy-dependent cell death in IDH1 mutant malignant astrocytoma.
BT317 is selective to the tumor microenvironment and demonstrated therapeutic efficacy both as a single agent and in combination TMZ in IDH mutant astrocytoma models.
Physicochemical Properties
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M.Wt
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315.71
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Formula
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C16H10ClNO4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(C(C1=O)=CC2=C(O1)C=CC(Cl)=C2)NC3=CC=C(O)C=C3
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References
1. Douglas C, et al. bioRxiv. 2023 Apr 17:2023.04.13.536816.
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