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TXS-8

Chemical Structure : TXS-8

CAS No.: 2411401-41-5

TXS-8 (TXS8)

Catalog No.: PC-47062Not For Human Use, Lab Use Only.

TXS-8 is a specific, small molecule binder of Rpn-6 with KD of 14 uM, Rpn-6 is a subunit of the 19S regulatory particle (RP) of 26s proteasome.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TXS-8 is a specific, small molecule binder of Rpn-6 with KD of 14 uM, Rpn-6 is a subunit of the 19S regulatory particle (RP) of 26s proteasome.
    TXS-8 showed binding affinity towards Rpn-6 in biochemical and cell-based assays.
    TXS-8 was also preferentially cytotoxic to cancer cell lines that require significant 26S proteasome activity for survival (MM.1R and Ramos B-cells, IC50=14 uM).
    TXS-8 exhibited no appreciable binding against other 19S RP subunit, including Rpn-13. a useful tool to further elucidate the role of Rpn-6.
    Rpn-6 is a proteasome-associated protein that makes critical contacts with the 19S regulatory particle (19S RP)and the 20S core particle (20S CP) of the proteasome.

    Physicochemical Properties

    M.Wt 572.750
    Formula C34H44N4O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(2-amino-2-oxoethyl)-2-(N-(4-(tert-butyl)benzyl)-2-((2-ethoxybenzyl)amino)acetamido)-N-(2-methylbenzyl)acetamide

    References

    1. Tian W, et al. ACS Chem Biol. 2020 Feb 21;15(2):554-561.

    2. Tian W, et al. Chembiochem. 2021 Jun 2;22(11):1961-1965.

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