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Chemical Structure : WZ-1831
Catalog No.: PC-49521Not For Human Use, Lab Use Only.
WZ-1831 is a potent and highly selective inhibitor of human constitutive proteasome chymotryptic activity (β5c) with IC50 of 10 nM, >500-fold selectivity over β5i (IC50=7.1 uM).
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WZ-1831 is a potent and highly selective inhibitor of human constitutive proteasome chymotryptic activity (β5c) with IC50 of 10 nM, >500-fold selectivity over β5i (IC50=7.1 uM).
WZ-1831 enters the cells to engage the proteasome target, potently and selectively kills multiple myeloma cells, and does so by synergizing with a β5i-selective inhibitor.
| M.Wt | 492.34 | |
| Formula | C25H29BN4O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wenhu Zhan, et al. J Med Chem. 2023 Jan 6. doi: 10.1021/acs.jmedchem.2c00733.
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