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WZ-1831

Chemical Structure : WZ-1831

CAS No.: 2892822-24-9

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WZ-1831 (WZ1831)

Catalog No.: PC-49521Not For Human Use, Lab Use Only.

WZ-1831 is a potent and highly selective inhibitor of human constitutive proteasome chymotryptic activity (β5c) with IC50 of 10 nM, >500-fold selectivity over β5i (IC50=7.1 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    WZ-1831 is a potent and highly selective inhibitor of human constitutive proteasome chymotryptic activity (β5c) with IC50 of 10 nM, >500-fold selectivity over β5i (IC50=7.1 uM).
    WZ-1831 enters the cells to engage the proteasome target, potently and selectively kills multiple myeloma cells, and does so by synergizing with a β5i-selective inhibitor.

    Physicochemical Properties

    M.Wt 492.34
    Formula C25H29BN4O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-(3-((2-(2-(1H-indol-3-yl)-2-oxoacetamido)-4-(tert-butylamino)-4-oxobutanamido)methyl)phenyl)boronic acid

    References

    1. Wenhu Zhan, et al. J Med Chem. 2023 Jan 6. doi: 10.1021/acs.jmedchem.2c00733.

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