TCL-1 | Rpn-13 inhibitor | Probechem Biochemicals

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Chemical Structure : TCL-1

TCL-1 (Rpn-13 inhibitor TCL1)

Catalog No.: PC-21188Not For Human Use, Lab Use Only.

TCL-1 is a non-covalent ligand targeting the Pru domain of Rpn-13, TCL-1 binds to the Pru domain at the Rpn-2 docking site, affects proteasome-mediated proteolysis.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TCL-1 is a non-covalent ligand targeting the Pru domain of Rpn-13, TCL-1 binds to the Pru domain at the Rpn-2 docking site, affects proteasome-mediated proteolysis.

Physicochemical Properties

M.Wt	477.76
Formula	C19H14BrClN4O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-(4-bromobenzyl)-6-(4-chlorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl)acetic acid

References

1. Loy CA, et al. Bioorg Med Chem Lett. 2023 Sep 13:129485.

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TCL-1 (Rpn-13 inhibitor TCL1)

Biological Activity

Physicochemical Properties

References

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