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TCL-1

Chemical Structure : TCL-1

CAS No.: 875165-39-2

TCL-1 (Rpn-13 inhibitor TCL1)

Catalog No.: PC-21188Not For Human Use, Lab Use Only.

TCL-1 is non-covalent inhibitor of the Pru (Pleckstrin-like receptor for ubiquitin) domain of Rpn-13, affects proteasome-mediated proteolysis.

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    Biological Activity

    TCL-1 is non-covalent inhibitor of the Pru (Pleckstrin-like receptor for ubiquitin) domain of Rpn-13, affects proteasome-mediated proteolysis.
    TCL-1 is shown to bind to the same surface as Rpn-2, which is a Rpn-13 binding partner within the 19S RP, with modest affinity (KD = 26 μM).
    TCL-1 affects proteasome-mediated proteolysis through an interaction with Rpn-13.

    Physicochemical Properties

    M.Wt 477.76
    Formula C19H14BrClN4O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-(3-(4-bromobenzyl)-6-(4-chlorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl)acetic acid

    References

    1. Loy CA, et al. Bioorg Med Chem Lett. 2023 Sep 13:129485.

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