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Chemical Structure : Epoxomicin
CAS No.: 134381-21-8
Catalog No.: PC-21916Not For Human Use, Lab Use Only.
Epoxomicin (BU-4061T) is a potent, selective and irreversible proteasome inhibitor, covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the proteasome and potently inhibits primarily the chymotrypsin-like activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $298 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Epoxomicin (BU-4061T) is a potent, selective and irreversible proteasome inhibitor, covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the proteasome and potently inhibits primarily the chymotrypsin-like activity.
Epoxomicin does not inhibit nonproteasomal proteases such trypsin, chymotrypsin, papain, calpain, and cathepsin B at concentrations of up to 50 uM.
Epoxomicin is a more potent inhibitor of the chymotrypsin-like activity than lactacystin and the peptide vinyl sulfone NLVS.
Epoxomicin also effectively inhibits NF-kappaB activation in vitro and potently blocks in vivo inflammation in the murine ear edema assay.
| M.Wt | 554.73 | |
| Formula | C28H50N4O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2S,3S)-N-((2S,3R)-3-Hydroxy-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxobutan-2-yl)-3-methyl-2-((2S,3S)-3-methyl-2-(N-methylacetamido)pentanamido)pentanamide |
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1. Hanada M, et al. J Antibiot (Tokyo). 1992 Nov;45(11):1746-52.
2. Meng L, et al. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10403-8.
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