Compound 14-100 | Hsp70 inhibitor | Probechem Biochemicals

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Chemical Structure : Compound 14-100

Compound 14-100 (Hsp70 inhibitor)

Catalog No.: PC-49415Not For Human Use, Lab Use Only.

Compound 14-100 is a small molecule, orally active inhibitor targeting pancreatic cancer cell chemotaxis in vitro and in vivo, inhibits Hsp70 coding genes.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Compound 14-100 is a small molecule, orally active inhibitor targeting pancreatic cancer cell chemotaxis in vitro and in vivo, inhibits Hsp70 coding genes.
Compound 14-100 exhibits potent inhibition of Hsp70 coding genes in pancreatic cancer cells.
Compound 14-100 enhances anti-tumor effect of gemcitabine. increases the expression of KRT14 and KRT16 genes.
Compound 14-100 inhibits metastasis of fluorescence-labeled BxPC-3 cells, which were transplanted into the pancreas of nude mice as a subcutaneously grown cancer fragment.

Physicochemical Properties

M.Wt	331.196
Formula	C17H12Cl2N2O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-chlorophenyl)(5-(4-chlorophenyl)-1-methyl-1H-pyrazol-4-yl)methanone

References

1. Okamoto S, et al. Biomed Pharmacother. 2022 Nov;155:113733.

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