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Chemical Structure : KDT-11
Catalog No.: PC-21187Not For Human Use, Lab Use Only.
KDT-11 is a specific, reversible peptidomimetic binder inhibitor of Rpn-13 with binding KD of 3 uM, selectively inhibit proliferation of a broad range of cancer cell lines (NCI60, IC50=5 uM), but not non-malignant cells.
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KDT-11 is a specific, reversible peptidomimetic binder inhibitor of Rpn-13 with binding KD of 3 uM, selectively inhibit proliferation of a broad range of cancer cell lines (NCI60, IC50=5 uM), but not non-malignant cells.
KDT-11 does not inhibit any of the known protein-protein interactions involving Rpn13, but blunts the ability of Rpn13 to activate the deubiquitylase activity of Uch37 in vitro.
KDT-11 blocks cell cycle progression at the G0/G1 to S boundary and drives subsequent apoptosis.
KDT-11 is a reversible binder to the Pru doman of Rpn-13.
| M.Wt | 1178.93 | |
| Formula | C66H89ClFN7O9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Paige Dickson, et al. Cell Chem Biol. 2020 Nov 19;27(11):1383-1395.e5.
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