Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-Proteasome/Ubiquitin-Proteasome-KDT-11
KDT-11

Chemical Structure : KDT-11

CAS No.:

KDT-11 (KDT11)

Catalog No.: PC-21187Not For Human Use, Lab Use Only.

KDT-11 is a specific, reversible peptidomimetic binder inhibitor of Rpn-13 with binding KD of 3 uM, selectively inhibit proliferation of a broad range of cancer cell lines (NCI60, IC50=5 uM), but not non-malignant cells.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
200 mg Get quote

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KDT-11 is a specific, reversible peptidomimetic binder inhibitor of Rpn-13 with binding KD of 3 uM, selectively inhibit proliferation of a broad range of cancer cell lines (NCI60, IC50=5 uM), but not non-malignant cells.
    KDT-11 does not inhibit any of the known protein-protein interactions involving Rpn13, but blunts the ability of Rpn13 to activate the deubiquitylase activity of Uch37 in vitro.
    KDT-11 blocks cell cycle progression at the G0/G1 to S boundary and drives subsequent apoptosis.
    KDT-11 is a reversible binder to the Pru doman of Rpn-13.

    Physicochemical Properties

    M.Wt 1178.93
    Formula C66H89ClFN7O9
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(14-amino-12-((1R,2R)-2-(benzyloxy)cyclopentyl)-3-(4-chlorophenethyl)-6-((R)-1-cyclohexylethyl)-9-(3,4-dimethoxyphenethyl)-2,5,8,11,14-pentaoxo-3,6,9,12-tetraazatetradecyl)-N-((R)-1-cyclohexylethyl)-2-((2-fluorobenzyl)(methyl)amino)acetamide

    References

    1. Paige Dickson, et al. Cell Chem Biol. 2020 Nov 19;27(11):1383-1395.e5.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: