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Brilaroxazine

Chemical Structure : Brilaroxazine

CAS No.: 1239729-06-6

Brilaroxazine (RP5063, RP-5063)

Catalog No.: PC-63187Not For Human Use, Lab Use Only.

RP-5063 (Brilaroxazine) is a multimodal dopamine and serotonin modulator with partial agonist activity at DA D2, D3, D4, 5-HT1A, and 5-HT2ARs, and antagonist activity at 5-HT2B, 5-HT6 and 5-HT7Rs.

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Biological Activity

RP-5063 (Brilaroxazine) is a multimodal dopamine and serotonin modulator with partial agonist activity at DA D2, D3, D4, 5-HT1A, and 5-HT2ARs, and antagonist activity at 5-HT2B, 5-HT6 and 5-HT7Rs.
RP-5063 produces dose-dependent reductions in pulmonary blood vessel wall thickness and proportion of muscular vessels, blocks MCT-induced increases in the plasma cytokines TNFα, IL-1β, and IL-6 in vivo.
RP-5063 prevents Sugen 5416-hypoxia-induced pulmonary arterial hypertension in rats.
RP-5063 improves declarative memory and psychosis in mouse models of schizophrenia.

Physicochemical Properties

M.Wt 450.36
Formula C22H25Cl2N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2H-benzo[b][1,4]oxazin-3(4H)-one

References

1. Bhat L, et al. Eur J Pharmacol. 2017 Sep 5;810:83-91.

2. Rajagopal L, et al. Behav Brain Res. 2017 Aug 14;332:180-199.

3. Bhat L, et al. Eur J Pharmacol. 2017 Sep 5;810:92-99.

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