Bryostatin 1 (NSC 339555) | PKC activator

Chemical Structure : Bryostatin 1

CAS No.: 83314-01-6

Bryostatin 1 (NSC 339555, Bryostatin1)

Catalog No.: PC-35396Not For Human Use, Lab Use Only.

Bryostatin 1 (NSC 339555) is a macrocyclic lactone derived from a marine invertebrate, fuctions as an activator of PKC with high binding affinity (Ki=1.35 nM).

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Biological Activity

Bryostatin 1 (NSC 339555) is a macrocyclic lactone derived from a marine invertebrate, fuctions as an activator of PKC with high binding affinity (Ki=1.35 nM).
Bryostatin 1 functions like the phorbol esters biochemically in binding to and activating protein kinase C.
Bryostatin 1 inhibits tumor promotion by phorbol esters in SENCAR mouse skin, induces differentiation of B-chronic lymphocytic leukemia cells.
Bryostatin 1 blocks phorbol ester action in Friend cells, restores the differentiation respons with EC50 of 15 nM.

Physicochemical Properties

M.Wt	905.044
Formula	C47H68O17
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4-Octadienoic acid, 25-(acetyloxy)-1,11,21-trihydroxy-17-(1-hydroxyethyl)-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl ester, [1S-[1R,3R,5Z,7S,8E,11R,12R*(2E,

References

1. Wender PA, et al. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6624-9.

2. Sako T, et al. Cancer Res. 1987 Oct 15;47(20):5445-50.

3. Dell'Aquila ML, et al. Cancer Res. 1987 Nov 15;47(22):6006-9.

4. Drexler HG, et al. Blood. 1989 Oct;74(5):1747-57.

Bryostatin 1 (NSC 339555, Bryostatin1)

Biological Activity

Physicochemical Properties

References

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