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Chemical Structure : Bumetanide
CAS No.: 28395-03-1
Catalog No.: PC-45286Not For Human Use, Lab Use Only.
Bumetanide (Ro 10-6338, PF-1593) is an inhibitor of Na(+)-K(+)-2Cl(-) co-transporter (NKCC) with an IC50 of 0.6 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $158 | In stock | |
| 200 mg | $248 | In stock | |
| 1 g | Get quote |
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Bumetanide (Ro 10-6338, PF-1593) is an inhibitor of Na(+)-K(+)-2Cl(-) co-transporter (NKCC) with an IC50 of 0.6 uM.
Bumetanide (Ro 10-6338, PF-1593) decreases internal chloride concentration in neurons.
Bumetanide (Ro 10-6338, PF-1593) inhibits ouabain-resistant 86Rb(K+) influx with IC50 of 0.1, 5.0, and 0.05 microM for J774.2, CT2 and J7H1 macrophages, respectively.
Bumetanide (Ro 10-6338, PF-1593) is a loop diuretic most often used to treat heart failure.
| M.Wt | 364.4161 | |
| Formula | C17H20N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Benzoic acid, 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy- |
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1. Frelin C, et al. Biochem Biophys Res Commun. 1986 Jan 14;134(1):326-31.
2. Bourrit A, et al. Biochim Biophys Acta. 1985 Jul 11;817(1):85-94.
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