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Chemical Structure : Butaselen
Catalog No.: PC-21339Not For Human Use, Lab Use Only.
Butaselen is a small molecule inhibitor of thioredoxin reductase (TrxR)/thioredoxin (Trx) with anti-tumor activity, inhibits the growth of various human cancer cell lines.
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Butaselen is a small molecule inhibitor of thioredoxin reductase (TrxR)/thioredoxin (Trx) with anti-tumor activity, inhibits the growth of various human cancer cell lines.
Butaselen protects mice from developing hepatocellular carcinoma, halts progression of hepatocarcinoma in mice models.
Butaselen induces G2/M arrest and apoptosis in hepatocellular carcinoma cells by inhibiting TrxR activity.
Butaselen inhibits the proliferation of HCC cell lines Bel7402, HepG2 and Huh7 in a dose- and time-dependent manner (IC50=8-20 uM).
Butaselen promotes NK and T cell activity and infiltration in the tumor microenvironment in HCC-bearing mice by enhancing the expression of CXCR3, NKG2D, and their respective ligands.
| M.Wt | 450.26 | |
| Formula | C18H16N2O2Se2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zheng X, et al. Redox Biol. 2018 Apr;14:237-249.
2. Su X, et al. J Immunol. 2023 Mar 1;210(5):681-695.
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