Chemical Structure : Butaselen
CAS No.:
857375-83-8
Butaselen
Catalog No.: PC-21339Not For Human Use, Lab Use Only.
Butaselen is a small molecule inhibitor of thioredoxin reductase (TrxR)/thioredoxin (Trx) with anti-tumor activity, inhibits the growth of various human cancer cell lines.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Butaselen is a small molecule inhibitor of thioredoxin reductase (TrxR)/thioredoxin (Trx) with anti-tumor activity, inhibits the growth of various human cancer cell lines.
Butaselen protects mice from developing hepatocellular carcinoma, halts progression of hepatocarcinoma in mice models.
Butaselen induces G2/M arrest and apoptosis in hepatocellular carcinoma cells by inhibiting TrxR activity.
Butaselen inhibits the proliferation of HCC cell lines Bel7402, HepG2 and Huh7 in a dose- and time-dependent manner (IC50=8-20 uM).
Butaselen promotes NK and T cell activity and infiltration in the tumor microenvironment in HCC-bearing mice by enhancing the expression of CXCR3, NKG2D, and their respective ligands.
Physicochemical Properties
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M.Wt
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450.26
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Formula
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C18H16N2O2Se2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2,2'-(butane-1,4-diyl)bis(benzo[d][1,2]selenazol-3(2H)-one)
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References
1. Zheng X, et al. Redox Biol. 2018 Apr;14:237-249.
2. Su X, et al. J Immunol. 2023 Mar 1;210(5):681-695.
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